JACKSONVILLE, Fla. — Despite losing star receiver Tyreek Hill early, Patrick Mahomes threw for 378 yards and three touchdowns while leading the Kansas City Chiefs to a testy and tactful 40-26 victory over the injury-riddled Jacksonville Jaguars on Sunday.

Mahomes took a beating and even had to leave the game to get his left ankle taped in the second quarter. He nonetheless looked every bit as good as he did during last year’s MVP campaign, leading the Chiefs to scores on each of their first seven possessions.

Jacksonville lost quarterback Nick Foles to a broken left clavicle.

Sammy Watkins caught nine passes for a career-high 198 yards and three TDs. Watkins slipped through the middle of Jacksonville’s defense for a 68-yard score on the third play of the season and added a 49-yard TD reception late in the opening quarter. He made defenders Ronnie Harrison, Jalen Ramsey and Miles Jack look silly while strolling into the end zone twice. He beat Ramsey again for a short TD in the fourth period.

PATRIOTS 33, STEELERS 3

FOXBOROUGH, Mass. — A day after the acquiring former Pittsburghs malcontent Antonio Brown, defending Super Bowl champions New England showed it might not even need him, getting 341 yards and three touchdown passes from 42-year-old Tom Brady.

Phillip Dorsett caught two touchdown passes, including a 58-yard score, and Josh Gordon — another disgruntled receiver who wore out his welcome elsewhere — caught one TD pass. On the night New England unveiled its sixth NFL championship banner, Super Bowl MVP Julian Edelman caught six passes for 83 yards and also completed a throw to help the Patriots begin their quest for back-to-back titles.

Facing the last team to beat them, the Patriots opened a 20-0 lead before Pittsburgh kicked a field goal on fourth-and-goal from the 1 with 10:17 left in the third quarter. Brady responded with a 58-yard touchdown pass to Dorsett and a 27-3 lead.  Dorsett, who will be moving down the depth chart Monday when the Patriots make Brown’s signing official, had four catches for 95 yards and the first multi-score game of his career.

LIONS 27, CARDINALS 27, OT

GLENDALE, Ariz. — Kyler Murray and the Cardinals nearly finished an improbable comeback in the rookie’s debut, rallying from an 18-point deficit in the fourth quarter to tie the game.

The Cardinals had two chances to win in extra time and so did the Lions, but all they could do was trade field goals and settle for a tie.

It was a strange ending to a thrilling game.

Arizona’s new-look offense under first-year coach Kliff Kingsbury was a dud for most of the afternoon before inexplicably coming alive in the fourth quarter. Murray hit David Johnson for a 27-yard touchdown to pull the Cardinals within 24-16 with less than six minutes remaining.

After the defense stopped the Lions, the top overall draft pick was at it again, leading a nine-play, 60-yard drive to a 4-yard TD throw to Larry Fitzgerald. Murray found Christian Kirk on a 2-point conversion to tie it with 43 seconds left.

TITANS 43, BROWNS 13

CLEVELAND — Marcus Mariota threw three touchdown passes — one a stunning 75-yarder to big back Derrick Henry — and the Browns fell flat on their faces in their highly anticipated opener.

Titans tight end Delanie Walker had two TD catches in the fourth, and Tennessee’s defensive backs intercepted Baker Mayfield three times in the fourth period.

Cameron Wake sacked Mayfield in the end zone for a safety in the first half, and the Titans dominated the undisciplined and perhaps overblown Browns, picked by some to contend for a Super Bowl title after adding Odell Beckham Jr. The Browns committed 18 penalties for 182 yards, a poor reflection on first-year coach Freddie Kitchens. Cleveland also had a player ejected for kicking a Titans defender.

RAVENS 59, DOLPHINS 10

MIAMI GARDENS, Fla. —Lamar Jackson looked unstoppable from the start and tied a franchise record with five touchdown passes to help the Ravens humiliate the Dolphins and rookie coach Brian Flores.

The Ravens set a franchise record for points in the first half, and an NFL record for points in the first half of an opener, taking a 42-10 lead at the break. They broke franchise marks for points and total yards with 643.

Baltimore gained 49 yards on the first play — a run by newcomer Mark Ingram — and hardly slowed down after that. Jeers began when the score reached 14-0, evidence of the impending avalanche already obvious.

RAMS 30, PANTHERS 27

CHARLOTTE, N.C. — Malcolm Brown ran for a pair of scores and Jared Goff threw for 186 yards and a touchdown.

Todd Gurley started and ran for 97 yards on 14 carries after being limited to 8 yards rushing on five carries in the first half. Brown was the primary ball carrier for the better part of three quarters and finished with 53 yards on 11 carries.

Christian McCaffrey led the Panthers with 209 yards from scrimmage and two touchdowns.

EAGLES 32, WASHINGTON 27

PHILADELPHIA — Carson Wentz threw a pair of deep touchdown passes to DeSean Jackson, and the Eagles overcame a 17-point deficit. Wentz was 28 of 39 for 313 yards and three TDs in his first game since Week 14 after not taking a snap in the preseason. Jackson had eight catches for 154 yards. The Eagles racked up 436 total yards.

Case Keenum threw for 380 yards and three TDs, helping Washington build a 17-0 lead in his first start with his fourth team in four seasons. But Philadelphia’s high-powered offense took over and the defense settled down after a sloppy start.

VIKINGS 28, FALCONS 12

MINNEAPOLIS — Anthony Harris highlighted a thorough thrashing by Minnesota’s defense with two interceptions of Matt Ryan and a fumble recovery.

Dalvin Cook carried a revived running attack, while Eric Wilson recovered his own blocked punt at the Atlanta 21-yard line on the first possession of the game, and the Vikings were well on their way to winning a fourth straight opener. Including the blocked punt, their first in five years, they turned all four Falcons turnovers into touchdowns.

Kirk Cousins connected with Adam Thielen for a 23-yard score to finish the short first drive and crossed the goal line on a 1-yard sneak in the second quarter to cap a 79-yard march to give Minnesota a 21-0 lead. Cousins went 8 for 10 for 98 yards, all career lows for games he started, but there was no need for more.

BILLS 17, JETS 16

EAST RUTHERFORD, N.J. — Josh Allen threw a 38-yard touchdown pass to John Brown with 3 minutes left, and the Bills rallied from a 16-point second-half deficit.

After struggling to get much going on offense, the Bills finally were able to move the ball after Jets middle linebacker C.J. Mosley left with a groin injury.

Buffalo also took advantage of kicking woes by the Jets as Kaare Vedvik, claimed last week off waivers from Minnesota, missed an extra point and a 45-yard field goal and ended up being the difference in the game.

CHARGERS 30, COLTS 24, OT

CARSON, Calif. — Austin Ekeler scored three touchdowns, including the winner on a 7-yard run with 5:01 remaining in overtime.

The Chargers got the ball to start overtime and went 75 yards on eight plays. Ekeler, the Chargers’ lead back with Melvin Gordon holding out for a new contract, had 154 all-purpose yards on the day. He ran for 58 yards on 10 carries and caught six passes for 96 yards and two scores.

Philip Rivers, who made his 209th consecutive start to pass Peyton Manning for third longest among NFL QBs, completed 25 of 34 passes for 333 yards. It is the fifth time Rivers has thrown three or more TD passes in an opener.

COWBOYS 35, GIANTS 17

ARLINGTON, Texas — Dak Prescott tied his career high with four touchdown passes while throwing for 405 yards, and the Cowboys rolled up 494 yards.

Saquon Barkley ran 59 yards on his first carry of the season, setting up Eli Manning’s touchdown pass for a 7-0 lead. But the Giants simply couldn’t keep up with a Dallas offense eager to see what could happen at full strength.

As expected, Ezekiel Elliott didn’t seem to be in peak form after spending almost all of training camp trying to stay in shape in Mexico while waiting for the $90 million, six-year contract extension that was settled on the morning of the first full workout of the regular season.

49ERS 31, BUCCANEERS 17

TAMPA, Fla. — Richard Sherman and Ahkello Witherspoon returned two of a retooled San Francisco defense’s three interceptions of Jameis Winston for touchdowns and Robbie Gould kicked three field goals. Jimmy Garoppolo threw for 166 yards and one touchdown in his first game in nearly a year.

Winston threw for 194 yards to become Tampa Bay’s career passing leader, including a 10-yard scoring pass to Chris Godwin that trimmed a double-digit deficit to 20-14 late in the third quarter. Ultimately, though, the Bucs could not overcome the fifth-year quarterback’s mistakes and dropped their debut under coach Bruce Arians, who was lured out of retirement after Tampa Bay finished 5-11 last season and missed the playoffs for the 11th straight year.

Garoppolo, who missed most of last season with a knee injury, completed 18 of 27 passes with one interception. His 39-yard pass to Richie James Jr. put the 49ers ahead for good early in the second half.

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